UT Health Houston, McGovern Medical School.
Houston, Texas
As a physician-scientist trained in anesthesiology, Dr. Eltzschig’s research has been funded by the NIH over many years to study perioperative organ injury. Many surgical patients experience acute organ injury in the perioperative period, leading to morbidity and mortality. Our research laboratory is interested in endogenous adaptive pathways that are controlled by hypoxia-inducible factors (HIFs). We have shown that activation of hypoxia-signaling during inflammatory conditions represents an endogenous adaptive pathway that can be targeted therapeutically. We have applied these molecular concepts to diseases that are important to the field of perioperative medicine, including acute kidney injury, myocardial or hepatic ischemia, intestinal inflammation and acute lung injury. Our studies point towards an adaptive role for HIFs, for example by attenuating hypoxia-associated inflammation or promoting ischemia tolerance. It is our hope that these studies will contribute to novel pharmacologic approaches to prevent or treat acute organ injury. For example, we are currently performing a multi-center, randomized, placebo-controlled clinical trial in ARDS patients using the HIF activator vadadustat for ARDS prevention or therapy. Many of his previous trainees became independently funded investigators or obtained academic leadership roles.
Dr. Eltzschig has published over 310 peer-reviewed research contributions, including first or senior author papers in Nature Medicine, Nature Immunology, Circulation, Gastroenterology, Gut, Science Translational Medicine, The Journal of Clinical Investigations, The Journal of Experimental Medicine, PLoS Medicine, PLoS Biology, Circulation Research, Blood, PNAS, Nature Communications, and many other leading biomedical journals. Dr. Eltzschig is also the lead author of three review papers in the New England Journal of Medicine. In addition, he published review papers in Nature, Nature Medicine, Blood, Anesthesiology, and Nature Reviews Drug Discovery that focus on his research findings. With an H-index of 97 and over 35,500 citations, Dr. Eltzschig is among the highest-cited-physician-scientists from the field of perioperative medicine.
Effects of Hypoxia on Organ Function
ACVAA Diplomates/Residents Emphasis
Friday, October 13, 2023
8:00 AM – 9:15 AM
Panel Discussion
ACVAA Diplomates/Residents Emphasis
Friday, October 13, 2023
5:15 PM – 6:00 PM
Targeting Hypoxia Signaling for Lung Protection
One Health: Critical Topics in Trauma Medicine
Saturday, October 14, 2023
9:00 AM – 9:30 AM